Determine which one of the five steps of the pyruvate dehydrogenase complex reaction is metabolically irreversible and briefly explain why. – 2017

determine which one of the five steps of the pyruvate dehydrogenase complex reaction is metabolically irreversible and briefly explain why.



the decarboxylation step, since the CO₂ product is rapidly hydrated to bicarbonate. (The other 4 rxns are transfer rxns or oxidation-reduction rxns that are more easily reversed)



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